Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:691944 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
691944692405462riboflavin synthase subunit betaQuickGO ontologyBLASTP
6927246937431020electron transport complex protein RnfGNqrCQuickGO ontologyBLASTP
693837694232396hypothetical protein
694390695022633putative poly A polymeraseQuickGO ontologyBLASTP
695073695591519peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
6956406975591920NAD synthetaseQuickGO ontologyBLASTP
697760698200441hypothetical proteinBLASTP
698197699138942hypothetical proteinBLASTP
699185699547363hypothetical proteinBLASTP
700107701012906D-alanylalanine synthetaseQuickGO ontologyBLASTP
7010227024671446transcriptional regulatory proteinQuickGO ontologyBLASTP
702576703298723hypothetical protein
7034027068753474ATP-dependent nuclease subunit BQuickGO ontologyBLASTP
7069317080311101hypothetical proteinBLASTP
708021708554534RNA polymerase sigma factor sigVQuickGO ontologyBLASTP
7094797115542076hypothetical proteinBLASTP
7116347131511518putative S-layer proteininternalin A-likeN-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
71328671336075tRNA-GluQuickGO ontology
7134697156312163DNA helicase IIQuickGO ontologyBLASTP