Pre_GI: BLASTP Hits

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Query: NC_009699:3940984:3961121 Clostridium botulinum F str. Langeland chromosome, complete genome

Start: 3961121, End: 3961198, Length: 78

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:3939328:39591573959157395923377Clostridium botulinum F str. 230613 chromosome, complete genometRNA-Val7e-0752.8
NC_012563:4101000:41215034121503412158078Clostridium botulinum A2 str. Kyoto, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39243363924336392441378Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39589783958978395905578Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_012563:4101000:41211634121163412124078Clostridium botulinum A2 str. Kyoto, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39586383958638395871578Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39239963923996392407378Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39583293958329395840678Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39236873923687392376478Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_012563:4101000:41208544120854412093178Clostridium botulinum A2 str. Kyoto, complete genometRNA-Val7e-0752.8
NC_009699:3940984:39614613961461396153878Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39433893943389394346678Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39436983943698394377578Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39440383944038394411578Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_010723:485874:50150050150050157778Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Val4e-0650.1
NC_010723:485874:50177150177150184878Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Val4e-0650.1