Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3938490 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39384903938975486hypothetical proteinBLASTP
39390823939513432hypothetical proteinBLASTP
39396943940599906transcriptional regulator LysR familyQuickGO ontologyBLASTP
394068739418831197subtilase family proteinQuickGO ontologyBLASTP
39419163942797882transcriptional regulator LysR familyQuickGO ontologyBLASTP
39428263943773948D-isomer specific 2-hydroxyacid dehydrogenaseQuickGO ontologyBLASTP
39439893944828840acetyl-CoA carboxylase carboxyl transferase alpha subunitQuickGO ontologyBLASTP
39448753945744870acetyl-CoA carboxylase carboxyl transferase beta subunitQuickGO ontologyBLASTP
394576439471101347acetyl-CoA carboxylase biotin carboxylaseQuickGO ontologyBLASTP
39471423947576435beta-hydroxyacyl-acyl-carrier-protein dehydratase FabZQuickGO ontologyBLASTP
39475963948072477acetyl-CoA carboxylase biotin carboxyl carrier proteinQuickGO ontologyBLASTP
3948076394931412393-oxoacyl-acyl-carrier-protein synthase IIQuickGO ontologyBLASTP
394933439500807473-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
39500983951042945malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
39510633951989927oxidoreductase 2-nitropropane dioxygenase familyQuickGO ontologyBLASTP
39521153952339225acyl carrier proteinQuickGO ontologyBLASTP
395238039533609813-oxoacyl-acyl-carrier-protein synthase IIIQuickGO ontologyBLASTP
39533533953829477transcriptional regulator MarR familyQuickGO ontologyBLASTP
395384539549031059oxidoreductase 2-nitropropane dioxygenase familyQuickGO ontologyBLASTP
39550013955936936putative peptidaseQuickGO ontologyBLASTP
39561173957103987putative DNA replication protein DnaDQuickGO ontologyBLASTP
39570963958073978putative DNA replication protein DnaCQuickGO ontologyBLASTP
3958164395823976tRNA-ThrQuickGO ontologyBLASTP
3958243395832179tRNA-AspQuickGO ontology
3958329395840678tRNA-ValQuickGO ontologyBLASTP
3958422395849877tRNA-GluQuickGO ontologyBLASTP
3958554395863279tRNA-AspQuickGO ontology
3958638395871578tRNA-ValQuickGO ontologyBLASTP
3958732395880877tRNA-GluQuickGO ontologyBLASTP
3958813395888876tRNA-ThrQuickGO ontologyBLASTP
3958892395897079tRNA-AspQuickGO ontology
3958978395905578tRNA-ValQuickGO ontologyBLASTP
3959072395914675tRNA-GluQuickGO ontology
39593173960126810hypothetical proteinBLASTP
39601393960513375CoA-binding proteinQuickGO ontologyBLASTP
396069439619231230pyridine nucleotide-disulphide oxidoreductase family proteinQuickGO ontologyBLASTP
39620243962773750acyl-ACP thioesterase family proteinQuickGO ontologyBLASTP
39628763963061186hypothetical proteinBLASTP
396318639644721287adenylosuccinate synthetaseQuickGO ontologyBLASTP
396470439660891386pyridine nucleotide-disulphide oxidoreductase family proteinQuickGO ontologyBLASTP
39662593966474216hypothetical proteinBLASTP
396667939684001722phosphoglucomutasephosphomannomutase family proteinQuickGO ontologyBLASTP
396864239699791338replicative DNA helicaseQuickGO ontologyBLASTP
397001039719291920ATP-dependent proteaseQuickGO ontologyBLASTP
39719403972383444ribosomal protein L9QuickGO ontologyBLASTP
397238339743681986DHH family proteinQuickGO ontologyBLASTP
397436939753731005hypothetical proteinBLASTP
39753853975702318hypothetical proteinBLASTP
39758513976093243ribosomal protein S18QuickGO ontologyBLASTP