Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:4101000 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
41010274101512486hypothetical proteinBLASTP
41016194102050432hypothetical proteinBLASTP
41022314103136906transcriptional regulator LysR familyQuickGO ontologyBLASTP
410322441044201197subtilase family proteinQuickGO ontologyBLASTP
41044564105337882transcriptional regulator LysR familyQuickGO ontologyBLASTP
41053664106313948D-isomer specific 2-hydroxyacid dehydrogenaseQuickGO ontologyBLASTP
41065134107352840acetyl-CoA carboxylase carboxyl transferase alpha subunitQuickGO ontologyBLASTP
41073994108268870acetyl-CoA carboxylase carboxyl transferase beta subunitQuickGO ontologyBLASTP
410828841096341347acetyl-CoA carboxylase biotin carboxylase subunitQuickGO ontologyBLASTP
41096664110100435beta-hydroxyacyl-acyl-carrier-protein dehydratase FabZQuickGO ontologyBLASTP
41101204110596477acetyl-CoA carboxylase biotin carboxyl carrier proteinQuickGO ontologyBLASTP
4110600411183812393-oxoacyl-acyl-carrier-protein synthase IIQuickGO ontologyBLASTP
411185841126047473-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
41126224113566945malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
41135874114513927oxidoreductase 2-nitropropane dioxygenase familyQuickGO ontologyBLASTP
41146394114863225acyl carrier proteinQuickGO ontologyBLASTP
411490441158849813-oxoacyl-acyl-carrier-protein synthase IIIQuickGO ontologyBLASTP
41158774116353477transcriptional regulator MarR familyQuickGO ontologyBLASTP
411636941174271059oxidoreductase 2-nitropropane dioxygenase familyQuickGO ontologyBLASTP
41175254118460936putative peptidaseQuickGO ontologyBLASTP
41186414119627987putative DNA replication protein DnaDQuickGO ontologyBLASTP
41196204120597978putative DNA replication protein DnaCQuickGO ontologyBLASTP
4120689412076476tRNA-ThrQuickGO ontologyBLASTP
4120768412084679tRNA-AspQuickGO ontology
4120854412093178tRNA-ValQuickGO ontologyBLASTP
4120947412102377tRNA-GluQuickGO ontologyBLASTP
4121079412115779tRNA-AspQuickGO ontology
4121163412124078tRNA-ValQuickGO ontologyBLASTP
4121257412133377tRNA-GluQuickGO ontologyBLASTP
4121417412149579tRNA-AspQuickGO ontology
4121503412158078tRNA-ValQuickGO ontologyBLASTP
4121597412167175tRNA-GluQuickGO ontology
41218444122653810hypothetical proteinBLASTP