Pre_GI Gene

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Host: NC_012658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012658:3923546 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39235463924031486hypothetical proteinBLASTP
39241383924569432hypothetical proteinBLASTP
39247503925655906LysR family transcriptional regulatorQuickGO ontologyBLASTP
392574339269391197subtilase family proteinQuickGO ontologyBLASTP
39269753927856882LysR family transcriptional regulatorQuickGO ontologyBLASTP
39278853928832948D-isomer specific 2-hydroxyacid dehydrogenaseQuickGO ontologyBLASTP
39290483929887840acetyl-CoA carboxylase carboxyl transferase subunit alphaQuickGO ontologyBLASTP
39299343930803870acetyl-CoA carboxylase carboxyl transferase subunit betaQuickGO ontologyBLASTP
393082339321691347biotin carboxylaseQuickGO ontologyBLASTP
393220139326354353R-hydroxymyristoyl-ACP dehydrataseQuickGO ontologyBLASTP
39326553933131477acetyl-CoA carboxylase biotin carboxyl carrier proteinQuickGO ontologyBLASTP
3933135393437312393-oxoacyl-acyl carrier protein synthase IIQuickGO ontologyBLASTP
393439339351397473-ketoacyl-ACP reductaseQuickGO ontologyBLASTP
39351573936101945malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
393612239370489272-nitropropane dioxygenase family oxidoreductaseQuickGO ontologyBLASTP
39371753937399225acyl carrier proteinQuickGO ontologyBLASTP
393744039384209813-oxoacyl-ACP synthase IIIQuickGO ontologyBLASTP
39384133938889477MarR family transcriptional regulatorQuickGO ontologyBLASTP
3938905393996310592-nitropropane dioxygenase family oxidoreductaseQuickGO ontologyBLASTP
39400613940996936putative peptidaseQuickGO ontologyBLASTP
39411773942163987putative DNA replication protein DnaDQuickGO ontologyBLASTP
39421563943133978DNA replication protein DnaCQuickGO ontologyBLASTP
3943224394329976tRNA-ThrQuickGO ontologyBLASTP
3943389394346678tRNA-ValQuickGO ontologyBLASTP
3943482394355877tRNA-GluQuickGO ontologyBLASTP
3943698394377578tRNA-ValQuickGO ontologyBLASTP
3943792394386877tRNA-GluQuickGO ontologyBLASTP
3943873394394876tRNA-ThrQuickGO ontologyBLASTP
3944038394411578tRNA-ValQuickGO ontologyBLASTP
39443793945188810hypothetical proteinBLASTP
39452013945575375CoA-binding proteinQuickGO ontologyBLASTP
394575639469851230pyridine nucleotide-disulfide oxidoreductase family proteinQuickGO ontologyBLASTP