Pre_GI: BLASTP Hits

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Query: NC_008262:2649289:2698146 Clostridium perfringens SM101, complete genome

Start: 2698146, End: 2698234, Length: 89

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:2649289:26984142698414269850289Clostridium perfringens SM101, complete genometRNA-Leu2e-0961.2
NC_008262:784878:79983179983179991989Clostridium perfringens SM101, complete genometRNA-Leu2e-0857.4
NC_008262:2649289:26986812698681269876989Clostridium perfringens SM101, complete genometRNA-Leu2e-0857.4
NC_003366:842000:85702885702885711386Clostridium perfringens str. 13, complete genome2e-0754.7
NC_009922:1917271:19242391924239192432789Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu6e-0753.1
NC_009922:2590317:26047922604792260488089Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu6e-0753.1
NC_009922:2590317:25981522598152259824089Alkaliphilus oremlandii OhILAs, complete genometRNA-Leu6e-0753.1
NC_014614:2500301:25103622510362251045089Clostridium sticklandii, complete genometRNA-Leu6e-0752.8
NC_010723:173280:17745317745317754189Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Leu9e-0752.4
NC_009699:3839575:38775963877596387768489Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Leu3e-0650.8
NC_009699:3839575:38773153877315387740389Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Leu3e-0650.8
NC_009698:3647955:36480353648035364812389Clostridium botulinum A str. Hall chromosome, complete genometRNA-Leu3e-0650.8
NC_009089:1:30318303183040386Clostridium difficile 630, complete genometRNA-Leu8e-0649.3
NC_009089:1:32149321493223486Clostridium difficile 630, complete genometRNA-Leu8e-0649.3
NC_009089:117980:14687914687914696486Clostridium difficile 630, complete genometRNA-Leu8e-0649.3
NC_009089:117980:15228115228115236686Clostridium difficile 630, complete genometRNA-Leu8e-0649.3