Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:784878 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
784878785183306hypothetical proteinBLASTP
785429786079651deoxyuridine 5-triphosphate nucleotidohydrolaseQuickGO ontologyBLASTP
7865867878961311thiamine biosynthesis protein ThiCQuickGO ontologyBLASTP
7881357919353801phosphoribosylformylglycinamidine synthaseQuickGO ontologyBLASTP
792258792737480phosphoribosylaminoimidazole carboxylase catalytic subunitQuickGO ontologyBLASTP
792737793444708phosphoribosylaminoimidazole-succinocarboxamide synthaseQuickGO ontologyBLASTP
7934907949111422amidophosphoribosyltransferaseQuickGO ontologyBLASTP
7949127959131002phosphoribosylformylglycinamidine cyclo-ligaseQuickGO ontologyBLASTP
795901796515615phosphoribosylglycinamide formyltransferaseQuickGO ontologyBLASTP
7965287980331506phosphoribosylaminoimidazolecarboxamide formyltransferaseIMP cyclohydrolaseQuickGO ontologyBLASTP
7981497993991251phosphoribosylamine--glycine ligaseQuickGO ontologyBLASTP
79983179991989tRNA-LeuQuickGO ontologyBLASTP
800340800657318ISCpe2 transposase orfAQuickGO ontologyBLASTP
8006688018221155ISCpe2 transposase orfBQuickGO ontologyBLASTP
801988802350363Domain of unknown function DUF307 familyQuickGO ontologyBLASTP
8030208040421023ISCpe7 transposaseQuickGO ontologyBLASTP
804166804708543rubredoxinrubrerythrinQuickGO ontologyBLASTP
805105805752648transaldolase putativeQuickGO ontologyBLASTP
806227806328102ISCpe5 transposaseQuickGO ontologyBLASTP
806344806703360ISCpe5 transposaseQuickGO ontologyBLASTP
806755807021267ISCpe5 transposaseQuickGO ontologyBLASTP
807225807704480Fibronectin type III domain proteinQuickGO ontologyBLASTP
8081768091891014phospho-2-dehydro-3-deoxyheptonate aldolaseQuickGO ontologyBLASTP
80931081036210533-dehydroquinate synthaseQuickGO ontologyBLASTP
81038581165912753-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
8117238127961074chorismate synthaseQuickGO ontologyBLASTP
812966813259294chorismate mutaseQuickGO ontologyBLASTP
814079814894816shikimate 5-dehydrogenaseQuickGO ontologyBLASTP
815057815560504shikimate kinaseQuickGO ontologyBLASTP
8156278160674413-dehydroquinate dehydratase type IIQuickGO ontologyBLASTP
816145816660516hypothetical proteinBLASTP
816830817672843hypothetical proteinBLASTP
817798818688891ATP-binding transport protein nataQuickGO ontologyBLASTP
8186908199011212hypothetical proteinBLASTP
820431820913483transcriptional regulator AsnC familyQuickGO ontologyBLASTP
8209108220881179aspartate aminotransferaseQuickGO ontologyBLASTP
8222038232281026hypothetical protein
823285823758474hypothetical protein
824477824980504acetyltransferase GNAT familyQuickGO ontologyBLASTP
8253008265021203DHHA1 domain proteinQuickGO ontologyBLASTP
8265578275611005glycosyl transferase group 2 family protein domain proteinQuickGO ontologyBLASTP
8277118288861176probable permease putativeQuickGO ontologyBLASTP
829152829910759transcriptional regulator DeoR familyQuickGO ontologyBLASTP