Pre_GI Gene

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Host: NC_017160 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017160:4508000 Yersinia pestis D182038 chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45080564508985930hypothetical proteinBLASTP
450898745102311245acetyl-CoA carboxylaseQuickGO ontologyBLASTP
45107544511707954putative iron transport proteinQuickGO ontologyBLASTP
45118314512676846iron transport permeaseQuickGO ontologyBLASTP
451266645136731008putative iron transport permeaseQuickGO ontologyBLASTP
45136704514428759putative iron ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
45144254514925501hypothetical proteinBLASTP
45164544516816363putative regulatorQuickGO ontologyBLASTP
451847445198531380hypothetical proteinBLASTP
451984045210331194putative phage integraseQuickGO ontologyBLASTP
4521199452128991tRNA-SecQuickGO ontologyBLASTP
452141945226121194putative AraC-family transcriptional regulatorQuickGO ontologyBLASTP
452270245238861185sugar transport system permeaseQuickGO ontologyBLASTP
45238734524403531sugar transport ATP-binding proteinQuickGO ontologyBLASTP
452440045254041005sugar transport ATP-binding proteinQuickGO ontologyBLASTP
45256124526607996sugar-binding periplasmic proteinQuickGO ontologyBLASTP
452707045283891320xylose isomeraseQuickGO ontologyBLASTP
452851345299671455xylulose kinaseQuickGO ontologyBLASTP
45300854531068984hypothetical proteinBLASTP