Pre_GI Gene

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Host: NC_007613 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007613:3470314 Shigella boydii Sb227, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
346919034703171128putative transporterQuickGO ontologyBLASTP
347031434729982685putative ATP-binding component of a transport system fragment 1QuickGO ontologyBLASTP
347304634741131068hypothetical proteinBLASTP
34750253475528504IS1 ORF2QuickGO ontologyBLASTP
34756033475815213putative IS1 encoded proteinQuickGO ontologyBLASTP
347577734767901014hypothetical proteinBLASTP
347705234780651014hypothetical proteinBLASTP
34789983479168171putative IS1 encoded proteinQuickGO ontologyBLASTP
34792513479763513IS1 ORF2QuickGO ontologyBLASTP
347980034808521053hypothetical proteinBLASTP
348116734823691203hypothetical proteinBLASTP
348260134841001500low affinity phosphate transportQuickGO ontologyBLASTP
34843443484679336hypothetical proteinBLASTP
34850703485504435universal stress proteinQuickGO ontologyBLASTP
348582234872911470putative transport proteinQuickGO ontologyBLASTP
34873403488092753hypothetical proteinBLASTP
348810034901422043oligopeptidase AQuickGO ontologyBLASTP
34903453491187843hypothetical proteinBLASTP
349125934926111353glutathione oxidoreductaseQuickGO ontologyBLASTP
34934873493840354transcriptional repressor of chromosomal ars operonQuickGO ontologyBLASTP
349387434951841311arsenical pump membrane proteinQuickGO ontologyBLASTP
34951973495622426arsenate reductaseQuickGO ontologyBLASTP
34957563496052297hypothetical proteinBLASTP
34964133497252840IS911 ORF2QuickGO ontologyBLASTP
34980553498849795hypothetical proteinBLASTP
34994943500093600SlpQuickGO ontologyBLASTP
35002493500779531hypothetical proteinBLASTP
35015323501870339hypothetical proteinBLASTP
35019743502306333hypothetical proteinBLASTP
35025613503133573hypothetical proteinBLASTP
35039323504459528hypothetical proteinBLASTP
350479835059551158hypothetical proteinBLASTP
350598035090933114putative transport system permease proteinQuickGO ontologyBLASTP