Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_007613: Shigella boydii Sb227, complete genome

NCBI: NC_007613

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
176123478018918956Island text1.5569927.490730.9051Neighbours41BLASTN+IslandViewer 761234.gbk
286408489531131228Island text4.2054842.680927.5102Neighbours41BLASTNIslandViewer 864084.gbk
31038000106059922600Island text1.5579730.569728.6013Neighbours41BLASTN+IslandViewer 1038000.gbk
41353500*137891925420Island text2.2174634.736421.057Neighbours41BLASTN+IslandViewer 1353500.gbk
51533024155939726374Island text2.1054730.429816.5286Neighbours41BLASTN+IslandViewer 1533024.gbk
62376974*240022423251Island text2.1574431.424919.4126Neighbours41BLASTN+IslandViewer 2376974.gbk
72699500*272161822119Island text1.6747630.119226.3918Neighbours41BLASTNIslandViewer 2699500.gbk
82981829300438522557Island text1.839329.731928.6545Neighbours41BLASTNIslandViewer 2981829.gbk
93470314350909338780Island text1.7727128.568324.1276Neighbours41BLASTN+IslandViewer 3470314.gbk
103637832*366214824317Island text2.5855435.392217.016Neighbours41BLASTNIslandViewer 3637832.gbk
114119771413859918829Island text1.6006728.933624.5158Neighbours41BLASTN+IslandViewer 4119771.gbk
124156841418149124651Island text1.5155932.824722.1464Neighbours41BLASTN+4156841.gbk
134217557*425611838562Island text1.5961728.405523.5639Neighbours41BLASTN+ PAI DB4217557.gbk
144403070442929526226Island text2.0049233.230725.6256Neighbours41BLASTNIslandViewer PAI DB4403070.gbk