Pre_GI Gene

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Host: NC_005810 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005810:1976000 Yersinia pestis biovar Microtus str. 91001, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
197631419794963183beta-D-galactosidaseQuickGO ontologyBLASTP
19800371980249213cold shock proteinQuickGO ontologyBLASTP
19804641980655192hypothetical proteinBLASTP
19831761983346171hypothetical proteinBLASTP
19836861984396711Mg2 transport ATPase protein CQuickGO ontologyBLASTP
198479719874962700Mg2 transport ATPase protein BQuickGO ontologyBLASTP
19890361989620585transcriptional activator FlhCQuickGO ontologyBLASTP
19898251990712888flagellar motor protein MotAQuickGO ontologyBLASTP
199070919920101302flagellar motor protein MotBQuickGO ontologyBLASTP
199202119941922172chemotaxis protein CheAQuickGO ontologyBLASTP
19943551994852498purine-binding chemotaxis proteinQuickGO ontologyBLASTP
199514419963791236hypothetical proteinBLASTP
19963921996799408YjgF-family lipoproteinQuickGO ontologyBLASTP
19967661997752987hypothetical proteinBLASTP
19979301998607678putative DNA-binding proteinQuickGO ontologyBLASTP