Pre_GI: BLASTP Hits

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Query: NC_005810:1976000:1996766 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 1996766, End: 1997752, Length: 987

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1715035:173692017369201737906987Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative L-xylulose-5-phosphate 3-epimerase0685
NC_014029:2607666:260668326066832607669987Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0685
NC_003143:1880000:190048419004841901470987Yersinia pestis CO92, complete genomehypothetical protein0685
NC_015177:2559903:2565527256552725671581632Pedobacter saltans DSM 12145 chromosome, complete genomeprotein of unknown function DUF10802e-1170.1
NC_016002:2037374:207623520762352077215981Pseudogulbenkiania sp. NH8B, complete genomexylose isomerase domain containing protein TIM barrel1e-0860.8
NC_013508:2587913:262162726216272622598972Edwardsiella tarda EIB202, complete genomexylose isomerase domain protein TIM barrel2e-0859.7
NC_013730:5914142:593087659308765931808933Spirosoma linguale DSM 74, complete genomeXylose isomerase domain protein TIM barrel2e-0653.5