Pre_GI Gene

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Host: NC_003997 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003997:2175843 Bacillus anthracis str. Ames, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21758432176178336hypothetical proteinBLASTP
21764742176686213hypothetical proteinBLASTP
21767562176962207hypothetical proteinBLASTP
217743121798932463penicillin-binding protein 1AQuickGO ontologyBLASTP
218050821816531146major facilitator family transporterQuickGO ontologyBLASTP
21816692181959291hypothetical proteinBLASTP
218236221834801119citrate synthaseQuickGO ontologyBLASTP
2183579218501514372-methylcitrate dehydrataseQuickGO ontologyBLASTP
21850342185942909carboxyvinyl-carboxyphosphonate phosphorylmutaseQuickGO ontologyBLASTP
218609721878061710acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
218782321887138912-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
218875021902101461methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
21902812190913633homoserinethreonine efflux protein putativeQuickGO ontologyBLASTP
219109721921521056enoyl-CoA hydrataseQuickGO ontologyBLASTP
21924692192726258hypothetical proteinBLASTP
21929102193149240hypothetical proteinBLASTP
219316521943221158exonuclease SbcD putativeQuickGO ontologyBLASTP
219431921974083090exonuclease putativeQuickGO ontologyBLASTP
21977772197977201hypothetical proteinBLASTP