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Query: NC_003997:2175843:2192910 Bacillus anthracis str. Ames, complete genome

Start: 2192910, End: 2193149, Length: 240

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2175867:219293421929342193173240Bacillus anthracis str. A0248, complete genomehypothetical protein2e-39160
NC_005957:2196000:221256522125652212804240Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-39160
NC_007530:2175967:219303421930342193273240Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-39160
NC_005945:2175871:219301621930162193255240Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-39160
NC_014335:2151404:216920121692012169440240Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-39160
NC_012472:2240000:225667122566712256910240Bacillus cereus 03BB102, complete genomehypothetical protein2e-39160
NC_011658:2275864:229239622923962292635240Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-39160
NC_011773:2239753:225686422568642257103240Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-39160
NC_011725:2206000:222334122233412223580240Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-36150
NC_011772:2166000:218290821829082183147240Bacillus cereus G9842, complete genomehypothetical protein4e-36149
NC_014171:2177353:219548521954852195724240Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-35148
NC_014915:2963500:296534029653402965582243Geobacillus sp. Y412MC52 chromosome, complete genomeProtein of unknown function DUF25842e-0960.8
NC_013411:597235:638353638353638595243Geobacillus sp. Y412MC61, complete genomeProtein of unknown function DUF25842e-0960.8