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Query: NC_003997:2175843:2181669 Bacillus anthracis str. Ames, complete genome

Start: 2181669, End: 2181959, Length: 291

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2175867:218169321816932181983291Bacillus anthracis str. A0248, complete genomehypothetical protein1e-49194
NC_011773:2239753:224562422456242245914291Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-49194
NC_005957:2196000:220132522013252201615291Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-49194
NC_012472:2240000:224544222454422245732291Bacillus cereus 03BB102, complete genomehypothetical protein1e-49194
NC_005945:2175871:218177521817752182065291Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-49194
NC_007530:2175967:218179321817932182083291Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-49194
NC_014335:2151404:215796221579622158252291Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-49192
NC_014171:2177353:218418021841802184470291Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-44177
NC_011725:2206000:221203622120362212326291Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-44177
NC_011658:2275864:228111522811152281405291Bacillus cereus AH187 chromosome, complete genomehypothetical protein3e-44176
NC_005945:3359598:337390633739063374196291Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-1786.3
NC_011772:2166000:217176421717642171892129Bacillus cereus G9842, complete genomehypothetical protein3e-1580.1
NC_013205:526281:560154560154560462309Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,HesB/YadR/YfhF-family protein5e-0960.1