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Query: NC_003997:2175843:2176474 Bacillus anthracis str. Ames, complete genome

Start: 2176474, End: 2176686, Length: 213

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2175867:217649821764982176710213Bacillus anthracis str. A0248, complete genomehypothetical protein6e-26116
NC_011773:2239753:224038722403872240599213Bacillus cereus AH820 chromosome, complete genomehypothetical protein6e-26116
NC_007530:2175967:217659821765982176810213Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein6e-26116
NC_011658:2275864:227586422758642276076213Bacillus cereus AH187 chromosome, complete genomehypothetical protein9e-26115
NC_005957:2196000:219603121960312196300270Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-26115
NC_005945:2175871:217644521764452176714270Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-26115
NC_012472:2240000:224021522402152240427213Bacillus cereus 03BB102, complete genomehypothetical protein6e-26115
NC_014335:2151404:215267721526772152937261Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein6e-26115
NC_014171:2177353:217898821789882179200213Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein7e-25112
NC_011725:2206000:220680522068052207017213Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-25112
NC_011772:2166000:216608021660802166292213Bacillus cereus G9842, complete genomehypothetical protein1e-24112