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Query: NC_016516:2380131:2400142 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Start: 2400142, End: 2400564, Length: 423

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016512:2388612:240862224086222409044423Propionibacterium acnes TypeIA2 P.acn17 chromosome, completehypothetical protein2e-67253
NC_016511:2389273:240928424092842409706423Propionibacterium acnes TypeIA2 P.acn31 chromosome, completehypothetical protein2e-67253
NC_014039:2386347:240635824063582406780423Propionibacterium acnes SK137 chromosome, complete genomehypothetical protein2e-67253
NC_011899:2286884:228907322890732289450378Halothermothrix orenii H 168, complete genomehypothetical protein2e-2097.4
NC_010718:1229355:123772312377231238076354Natranaerobius thermophilus JW/NM-WN-LF, complete genomeD-ornithine aminomutase S component2e-1788.2
NC_010003:1242846:125366012536601254046387Petrotoga mobilis SJ95, complete genomehypothetical protein3e-1477.4
NC_009718:1771500:179080817908081791191384Fervidobacterium nodosum Rt17-B1, complete genomehypothetical protein1e-1375.1
NC_016751:1604048:161303616130361613407372Marinitoga piezophila KA3 chromosome, complete genomehypothetical protein1e-1168.6