Pre_GI: BLASTP Hits

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Query: NC_012563:2566500:2577601 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2577601, End: 2578035, Length: 435

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:2479465:248959224895922490029438Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-73273
NC_011837:3226500:325833432583343258771438Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-48190
NC_009706:3291330:332683233268323327269438Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-48190
NC_009633:2592000:260324226032422603691450Alkaliphilus metalliredigens QYMF chromosome, complete genomePhage XkdN-like protein4e-41166
NC_011837:1935294:195487819548781955333456Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-33140
NC_009706:1935418:195502919550291955484456Clostridium kluyveri DSM 555 chromosome, complete genomeXkdN-like protein3e-32136
NC_010674:2817651:283540328354032835846444Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-31134
NC_013216:4404085:441111944111194411523405Desulfotomaculum acetoxidans DSM 771, complete genomeXkdN-like protein1e-29127
NC_013406:6052913:607060960706096071043435Paenibacillus sp. Y412MC10 chromosome, complete genomeXkdN-like protein1e-21102
NC_015520:595532:614030614030614455426Mahella australiensis 50-1 BON chromosome, complete genomeXkdN-like protein2e-21100
NC_014483:1179286:118657011865701187004435Paenibacillus polymyxa E681 chromosome, complete genomeXkdN-like protein3e-21100
NC_016641:2950000:295537829553782955812435Paenibacillus terrae HPL-003 chromosome, complete genomexkdn4e-2199.8
NC_014976:627935:662461662461662910450Bacillus subtilis BSn5 chromosome, complete genomeXkdN13e-1063.9
NC_000964:2670288:267687226768722677321450Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein2e-0961.2
NC_013406:6052913:605855360585536058975423Paenibacillus sp. Y412MC10 chromosome, complete genomeXkdN-like protein3e-0857
NC_009848:2755874:276631627663162766756441Bacillus pumilus SAFR-032, complete genomehypothetical protein6e-0856.2
NC_014976:3546884:354688435468843547330447Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein5e-0753.1
NC_019896:2719456:273568727356872736313627Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completePhage-like element PBSX protein XkdN7e-0752.8
NC_014479:1291500:129150112915011291947447Bacillus subtilis subsp. spizizenii str. W23 chromosome, completehypothetical protein6e-0752.8
NC_016047:1435961:143940914394091439855447Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completehypothetical protein6e-0752.8
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome1e-0651.6
NC_017195:1308730:131132713113271311773447Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completehypothetical protein3e-0650.8
NC_020244:1335531:133746913374691337915447Bacillus subtilis XF-1, complete genomehypothetical protein3e-0650.8
NC_013315:1707293:170819217081921708632441Clostridium difficile CD196 chromosome, complete genomephage protein7e-0649.3
NC_000964:1330000:133364813336481334274627Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein9e-0648.9