Pre_GI Gene

Some Help

Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:2817651 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
281594328176641722CspAQuickGO ontologyBLASTP
281765128194771827CspAQuickGO ontologyBLASTP
28194742819620147hypothetical protein
28204222820607186LexA DNA binding domainQuickGO ontologyBLASTP
28213572822148792cell wall binding repeat domain proteinQuickGO ontologyBLASTP
28222052822378174hypothetical proteinBLASTP
28223902822626237hypothetical proteinBLASTP
282270128237621062cell adhesion domain-containing proteinQuickGO ontologyBLASTP
282380828249891182cell adhesion domain-containing proteinQuickGO ontologyBLASTP
28254262825584159hypothetical protein
28255842825892309hypothetical proteinBLASTP
282590728271391233phage tail fiber domain proteinQuickGO ontologyBLASTP
28271362827786651hypothetical proteinBLASTP
282777328288941122hypothetical proteinBLASTP
28289002829340441hypothetical proteinBLASTP
28293332829674342hypothetical proteinBLASTP
282966428306831020hypothetical proteinBLASTP
28306912831380690hypothetical proteinBLASTP
28315062832096591putative lipoproteinQuickGO ontology
283213728351963060hypothetical proteinBLASTP
28352422835364123hypothetical protein
28354032835846444hypothetical proteinBLASTP
28359072836329423hypothetical proteinBLASTP
283635028377651416hypothetical proteinBLASTP