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Query: NC_010674:950276:952588 Clostridium botulinum B str. Eklund 17B, complete genome

Start: 952588, End: 953067, Length: 480

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021182:338428:339510339510339983474Clostridium pasteurianum BC1, complete genomehypothetical protein9e-43172
NC_002937:1764117:179892017989201799528609Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completehypothetical protein3e-0857.8
NC_018867:1837941:185056018505601851036477Dehalobacter sp. CF chromosome, complete genomehypothetical protein1e-0755.5
NC_012781:1968827:197620319762031976664462Eubacterium rectale ATCC 33656, complete genomehypothetical protein5e-0650.4
NC_004668:295417:307231307231307680450Enterococcus faecalis V583, complete genomehypothetical protein3e-0857.8
NC_018866:1790564:182078118207811821257477Dehalobacter sp. DCA chromosome, complete genomehypothetical protein1e-0755.5
NC_012563:1681639:170103417010341701531498Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein8e-34142
NC_015428:1483768:148929214892921489780489Lactobacillus buchneri NRRL B-30929 chromosome, complete genomehypothetical protein1e-0755.8
NC_009256:1253384:126737112673711267811441Burkholderia vietnamiensis G4 chromosome 1, complete sequencehypothetical protein1e-0652.4
NC_016791:1341858:134462613446261345120495Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein3e-35147
NC_013171:896802:913268913268913735468Anaerococcus prevotii DSM 20548, complete genomehypothetical protein4e-0753.9
NC_017208:694500:711657711657712193537Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage protein4e-0857.4
NC_008527:1036757:105116810511681051635468Lactococcus lactis subsp. cremoris SK11, complete genomePhage terminase, small subunit4e-0650.4