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Query: NC_010161:596034 Bartonella tribocorum CIP 105476, complete genome

Start: 596034, End: 620099, Length: 24066

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_012846:92957092957095327323704Bartonella grahamii as4aup, complete genome2e-44188BLASTN svgBLASTP svg
NC_010161:25482542548254257609927846Bartonella tribocorum CIP 105476, complete genome2e-32149BLASTN svgBLASTP svg
NC_012846:986877986877102533738461Bartonella grahamii as4aup, complete genome4e-30141BLASTN svgBLASTP svg
NC_010161:1179000*1179000119858119582Bartonella tribocorum CIP 105476, complete genome2e-29139BLASTN svgBLASTP svg
NC_010830:1836984*1836984187132134338Candidatus Amoebophilus asiaticus 5a2, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_010161:23811952381195240409922905Bartonella tribocorum CIP 105476, complete genome3e-1591.7BLASTN svgBLASTP svg
NC_012846:2154000*2154000217726123262Bartonella grahamii as4aup, complete genome5e-0867.9BLASTN svgBLASTP svg
NC_019978:1816940*1816940184397027031Halobacteroides halobius DSM 5150, complete genome3e-0661.9BLASTN svgBLASTP svg
NC_010161:1501758*1501758153237830621Bartonella tribocorum CIP 105476, complete genome3e-0661.9BLASTN svgBLASTP svg