Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:2381195 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23811952382100906geranyltranstransferaseQuickGO ontologyBLASTP
23832652383864600hypothetical proteinBLASTP
238464423858101167multidrug-efflux transporterQuickGO ontologyBLASTP
2386672238791312424-hydroxy-3-methylbut-2-en-1-yl diphosphate synthaseQuickGO ontologyBLASTP
23888292389131303hypothetical proteinBLASTP
238975123907581008secretion proteinQuickGO ontologyBLASTP
239078323924141632transport proteinQuickGO ontologyBLASTP
23924382392854417ATP synthase epsilon chainQuickGO ontologyBLASTP
239298123946061626F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
23946262395552927F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
239557323971081536F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
23971082397692585ATP synthase delta chainQuickGO ontologyBLASTP
23989982399276279hypothetical proteinBLASTP
23998022399993192hypothetical proteinBLASTP
24005472400696150hypothetical proteinBLASTP
240086524030722208primosome assembly protein PriAQuickGO ontologyBLASTP
24031862403335150integrase fragmentQuickGO ontologyBLASTP