Pre_GI Gene

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Host: NC_010161 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010161:1179000 Bartonella tribocorum CIP 105476, complete genome

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11790921179493402hypothetical proteinBLASTP
11799471180369423hypothetical protein
11804641180769306hypothetical protein
11814791181679201hypothetical proteinBLASTP
118188911830551167phage-related integraseQuickGO ontologyBLASTP
118325211842531002hypothetical proteinBLASTP
11842621184378117hypothetical proteinBLASTP
11843751185274900phage related proteinQuickGO ontologyBLASTP
118528211864121131phage related proteinQuickGO ontologyBLASTP
118666511898983234hypothetical proteinBLASTP
11899611190623663phage-related lysozymeQuickGO ontologyBLASTP
11906201190847228hypothetical proteinBLASTP
11909641191191228hypothetical proteinBLASTP
11913151191683369hypothetical proteinBLASTP
1191784119185976tRNA-ThrQuickGO ontology
119206211934201359acetyl-CoA carboxylase biotin carboxylase subunitQuickGO ontologyBLASTP
11934351193932498acetyl-CoA carboxylase biotin carboxyl carrier protein subunitQuickGO ontologyBLASTP
11941861195058873outer membrane proteinQuickGO ontologyBLASTP
119539511969241530glycerol-3-phosphate dehydrogenaseQuickGO ontologyBLASTP
11975981198581984tRNA-dihydrouridine synthase AQuickGO ontologyBLASTP