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Query: NC_003366:1901898:1923565 Clostridium perfringens str. 13, complete genome

Start: 1923565, End: 1924407, Length: 843

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:1795914:181292718129271813769843Clostridium perfringens SM101, complete genomehypothetical protein2e-157554
NC_008261:2117207:213887821388782139720843Clostridium perfringens ATCC 13124, complete genomehypothetical protein3e-157554
NC_014633:655693:671347671347672186840Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceRNA binding S1 domain-containing protein1e-48193
NC_021150:1677811:167781116778111678680870Azotobacter vinelandii CA6, complete genomeRNA binding protein, S1 family5e-45181
NC_012560:1677798:167779816777981678667870Azotobacter vinelandii DJ, complete genomeRNA binding protein, S1 family5e-45181
NC_014933:364463:367998367998368834837Bacteroides helcogenes P 36-108 chromosome, complete genomehypothetical protein2e-44179
NC_016602:2037162:203875920387592039595837Vibrio furnissii NCTC 11218 chromosome 1, complete sequenceRNA binding S1 domain-containing protein1e-42173
NC_013730:2187898:218899421889942189845852Spirosoma linguale DSM 74, complete genomehypothetical protein6e-42171
NC_008322:1898000:191664119166411917480840Shewanella sp. MR-7, complete genomehypothetical protein7e-42171
NC_010334:2131939:215396821539682154801834Shewanella halifaxensis HAW-EB4, complete genomehypothetical protein1e-41170
NC_004129:1741816:176479017647901765641852Pseudomonas fluorescens Pf-5, complete genomehypothetical protein6e-41167
NC_019978:2071435:207728220772822078109828Halobacteroides halobius DSM 5150, complete genomehypothetical protein6e-41167
NC_016026:1969766:199627519962751997147873Micavibrio aeruginosavorus ARL-13 chromosome, complete genome3-deoxy-7-phosphoheptulonate synthase1e-40167
NC_016830:1719407:173880917388091739645837Pseudomonas fluorescens F113 chromosome, complete genomerna binding s16e-40164
NC_015873:2260048:227737622773762278287912Megasphaera elsdenii DSM 20460, complete genomehypothetical protein8e-39160
NC_014935:595685:598865598865599782918Nitratifractor saLSUginis DSM 16511 chromosome, complete genomehypothetical protein3e-37155
NC_015496:2436089:243608924360892436922834Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomehypothetical protein4e-37155
NC_013173:1712138:171597117159711716801831Desulfomicrobium baculatum DSM 4028, complete genomenucleic acid binding protein2e-35149
NC_006138:225832:250352250352251182831Desulfotalea psychrophila LSv54, complete genomehypothetical protein4e-35148
NC_007498:3085511:310167931016793102503825Pelobacter carbinolicus DSM 2380, complete genomehypothetical protein1e-30133
NC_020125:1545578:154940715494071550231825Riemerella anatipestifer RA-CH-2, complete genomehypothetical protein2e-30132
NC_014738:167707:182616182616183440825Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,hypothetical protein2e-30132
NC_017045:328031:342940342940343764825Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,hypothetical protein2e-30132
NC_011725:1182000:118332311833231184177855Bacillus cereus B4264 chromosome, complete genomehypothetical protein5e-29128
NC_015678:966000:969278969278970132855Streptococcus parasanguinis ATCC 15912 chromosome, complete genomes1 RNA binding domain-containing protein1e-20100
NC_010163:285710:304481304481305332852Acholeplasma laidlawii PG-8A chromosome, complete genomehypothetical protein1e-1584