Pre_GI: BLASTN Hits

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Query: NC_002942:2943206 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Start: 2943206, End: 2964455, Length: 21250

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_006368:30282863028286305492626641Legionella pneumophila str. Paris, complete genome039530BLASTN svgBLASTP svg
NC_006369:28887012888701290683418134Legionella pneumophila str. Lens, complete genome032110BLASTN svgBLASTP svg
NC_013861:32156403215640323817522536Legionella longbeachae NSW150, complete genome2e-121444BLASTN svgBLASTP svg
NC_018697:361339*36133938386822530Cycloclasticus sp. P1 chromosome, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_015276:27690002769000279436025361Marinomonas mediterranea MMB-1 chromosome, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010501:3987615*3987615401756729953Pseudomonas putida W619, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_014909:86000*8600012150135502Candidatus Blochmannia vafer str. BVAF chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_010673:29167929167931681725139Borrelia hermsii DAH, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_007484:32319373231937325059618660Nitrosococcus oceani ATCC 19707, complete genome6e-0763.9BLASTN svgBLASTP svg
NC_002528:404545*40454542822723683Buchnera aphidicola str. APS (Acyrthosiphon pisum), complete6e-0763.9BLASTN svgBLASTP svg
NC_009654:29402782940278295966519388Marinomonas sp. MWYL1, complete genome2e-0661.9BLASTN svgBLASTP svg
NC_012880:3915500*3915500393874123242Dickeya dadantii Ech703, complete genome1e-0560BLASTN svgBLASTP svg
NC_005061:96536*9653614201245477Candidatus Blochmannia floridanus, complete genome1e-0560BLASTN svgBLASTP svg