Pre_GI Gene

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Host: NC_006368 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006368:3028286 Legionella pneumophila str. Paris, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain is endemic in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
302828630303222037hypothetical proteinBLASTP
30304663031380915UDP-3-O-3-hydroxymyristoyl N-acetylglucosamine deacetylaseQuickGO ontologyBLASTP
303162830328241197cell division protein FtsZQuickGO ontologyBLASTP
303301930342571239ATP-binding cell division protein FtsAQuickGO ontologyBLASTP
30342573034976720Cell division protein FtsQQuickGO ontologyBLASTP
303499230360861095D-alanine--D-alanine ligase AQuickGO ontologyBLASTP
30360703036981912UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
303700530384141410UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
303842430395991176Cell division protein ftsWQuickGO ontologyBLASTP
303960530409481344UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
304096230420471086Phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
304216230434991338UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alani ne ligaseQuickGO ontologyBLASTP
30437403044519780hypothetical proteinBLASTP
304452430480183495hypothetical proteinBLASTP
304897530500361062hypothetical proteinBLASTP
30503463051158813hypothetical proteinBLASTP
30512323051714483transcription elongation factor GreAQuickGO ontologyBLASTP
305172330549263204carbamoyl-phosphate synthase large subunitQuickGO ontologyBLASTP