Pre_GI Gene

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Host: NC_006369 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_006369:2888701 Legionella pneumophila str. Lens, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This serogroup I strain was responsible for a major outbreak in France. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
288870128898971197cell division protein FtsZQuickGO ontologyBLASTP
289009228913301239ATP-binding cell division protein FtsAQuickGO ontologyBLASTP
28913302892049720Cell division protein FtsQQuickGO ontologyBLASTP
289206528931591095D-alanine--D-alanine ligase AQuickGO ontologyBLASTP
28931432894069927UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
289407828954871410UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
289549728966721176Cell division protein ftsWQuickGO ontologyBLASTP
289667828980211344UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
289803528991201086Phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
289923529005721338UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alani ne ligaseQuickGO ontologyBLASTP
29008132901592780hypothetical proteinBLASTP
290159729050913495hypothetical proteinBLASTP
29052662905946681hypothetical proteinBLASTP
29059832906834852hypothetical protein