Pre_GI Gene

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Host: NC_017374 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017374:498588 Helicobacter pylori 2017 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
497936498595660cag island proteinQuickGO ontologyBLASTP
4985885000331446cag pathogenicity island proteinQuickGO ontologyBLASTP
500043500552510cag island proteinQuickGO ontologyBLASTP
500833500955123hypothetical proteinBLASTP
5010295032752247Type IV secretion system proteinQuickGO ontologyBLASTP
503284504276993ATPaseQuickGO ontologyBLASTP
504281504880600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5050165066171602cag pathogenicity island proteinQuickGO ontologyBLASTP
5066765080761401cag pathogenicity island proteinQuickGO ontologyBLASTP
5080915095391449cag island proteinQuickGO ontologyBLASTP
5097095113161608cag pathogenicity island proteinQuickGO ontologyBLASTP
511321512079759Inner membrane proteinQuickGO ontologyBLASTP
512460513116657cag pathogenicity island proteinQuickGO ontologyBLASTP
513152513994843cag pathogenicity island proteinQuickGO ontologyBLASTP
514176514775600cag pathogenicity island proteinQuickGO ontologyBLASTP
515200515403204cag pathogenicity island proteinQuickGO ontologyBLASTP
516593516730138hypothetical proteinBLASTP
5169655180951131cag island proteinQuickGO ontologyBLASTP