Pre_GI: BLASTP Hits

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Query: NC_017374:498588:515200 Helicobacter pylori 2017 chromosome, complete genome

Start: 515200, End: 515403, Length: 204

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017381:500699:517300517300517503204Helicobacter pylori 2018 chromosome, complete genomecag pathogenicity island protein1e-30131
NC_017357:495213:516179516179516382204Helicobacter pylori 908 chromosome, complete genomecag pathogenicity island protein1e-30131
NC_000915:547783:567142567142567522381Helicobacter pylori 26695, complete genomecag pathogenicity island protein (cag14)2e-30130
NC_000921:511642:530698530698531078381Helicobacter pylori J99, complete genomecag island protein9e-29125
NC_008086:513407:533301533301533681381Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein Q1e-28125
NC_011333:514464:535518535518535823306Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein Q3e-28123
NC_011498:553525:572815572815573195381Helicobacter pylori P12, complete genomecag pathogenicity island protein Q2e-27120
NC_017358:563336:581991581991582296306Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cagQ, cag14)5e-24109
NC_010698:819912:824858824858825163306Helicobacter pylori Shi470, complete genomecag island protein5e-24109
NC_017378:502806:521948521948522253306Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein (cagQ, cag14)1e-23108
NC_014555:502151:521273521273521578306Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein (cagQ, cag14)2e-23107
NC_017379:505350:524849524849525154306Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein4e-23106
NC_017355:493237:512701512701513006306Helicobacter pylori v225d chromosome, complete genomecag pathogenicity island protein2e-22104