Pre_GI: BLASTN Hits

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Query: NC_017374:498588 Helicobacter pylori 2017 chromosome, complete genome

Start: 498588, End: 518099, Length: 19512

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000921:51164251164253209920458Helicobacter pylori J99, complete genome06175BLASTN svgBLASTP svg
NC_000915:54778354778356859920817Helicobacter pylori 26695, complete genome05886BLASTN svgBLASTP svg
NC_011498:55352555352557409920575Helicobacter pylori P12, complete genome04742BLASTN svgBLASTP svg
NC_008086:51340751340753888425478Helicobacter pylori HPAG1, complete genome04579BLASTN svgBLASTP svg
NC_010698:81991281991284430024389Helicobacter pylori Shi470, complete genome04488BLASTN svgBLASTP svg