Pre_GI: BLASTP Hits

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Query: NC_017374:498588:516965 Helicobacter pylori 2017 chromosome, complete genome

Start: 516965, End: 518095, Length: 1131

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017381:500699:5190655190655201951131Helicobacter pylori 2018 chromosome, complete genomecag island protein0690
NC_017357:495213:5179445179445190741131Helicobacter pylori 908 chromosome, complete genomecag island protein0690
NC_017371:530673:5518285518285529581131Helicobacter pylori Gambia94/24 chromosome, complete genomecag island protein0685
NC_017063:800156:8213228213228224521131Helicobacter pylori ELS37 chromosome, complete genomecag pathogenicity island protein M0682
NC_008086:513407:5348825348825360121131Helicobacter pylori HPAG1, complete genomecag pathogenicity island protein M0682
NC_011333:514464:5371005371005382301131Helicobacter pylori G27 chromosome, complete genomecag pathogenicity island protein M0682
NC_017362:506950:5277535277535288831131Helicobacter pylori Lithuania75 chromosome, complete genomecag pathogenicity island protein M0682
NC_017378:502806:5240945240945252241131Helicobacter pylori Puno120 chromosome, complete genomecag pathogenicity island protein M0681
NC_017379:505350:5268855268855280151131Helicobacter pylori Puno135 chromosome, complete genomecag pathogenicity island protein M0679
NC_017367:562918:5839875839875851171131Helicobacter pylori F57, complete genomecag pathogenicity island protein0679
NC_017366:535188:5560545560545571841131Helicobacter pylori F32, complete genomecag pathogenicity island protein0679
NC_017358:563336:5840335840335851631131Helicobacter pylori Cuz20 chromosome, complete genomecag pathogenicity island protein (cagM, cag16)0677
NC_014555:502151:5233055233055244351131Helicobacter pylori PeCan4 chromosome, complete genomecag pathogenicity island protein (cagM, cag16)0671