Pre_GI Gene

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Host: NC_017328 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017328:3935185 Shigella flexneri 2002017 chromosome, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
393518539365401356putative Arabinose efflux permeaseQuickGO ontologyBLASTP
39365813936874294putative transport proteinQuickGO ontologyBLASTP
39374673938285819IS600 orfBQuickGO ontologyBLASTP
39383263939282957Serine protease sat precursorQuickGO ontologyBLASTP
39393703940359990Serine protease sat precursorQuickGO ontologyBLASTP
39404163940826411IS2 orfAQuickGO ontologyBLASTP
39424573943029573putative major fimbrial subunitQuickGO ontologyBLASTP
394332139446491329IS4 ORFQuickGO ontologyBLASTP
39469933947466474trimethoprim resistance proteintype I dihydrofolate reductaseQuickGO ontologyBLASTP
39475613948085525streptothricin acetyltransferaseQuickGO ontologyBLASTP
39481433948931789Streptomycin 3-adenylyltransferaseQuickGO ontologyBLASTP
39490073949504498hypothetical protein
39495653949936372hypothetical protein
39499693950292324hypothetical protein
39503463950723378hypothetical protein
395095439525701617Transposon Tn7 transposition protein tnsEQuickGO ontologyBLASTP
395257139540971527Transposon Tn7 transposition protein tnsDQuickGO ontologyBLASTP
395410039557671668Transposon Tn7 transposition protein tnsCQuickGO ontologyBLASTP
395576439578722109Transposon Tn7 transposition protein tnsBQuickGO ontologyBLASTP
39578593958680822Transposon Tn7 transposition protein tnsAQuickGO ontologyBLASTP