Pre_GI Gene

Some Help

Host: NC_012654 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012654:92487 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
92487935151029cell wall-associated hydrolaseQuickGO ontologyBLASTP
9359693781186hypothetical protein
9380794199393hypothetical protein
9422194361141hypothetical proteinBLASTP
9445194906456hypothetical proteinBLASTP
9503895628591ggdefgafhdig domain proteinQuickGO ontologyBLASTP
95756971741419DNA polymerase III subunits gamma and tauQuickGO ontologyBLASTP
9725897473216hypothetical proteinBLASTP
9748897631144hypothetical protein
9768198664984DNA polymerase III delta subunit superfamilyQuickGO ontologyBLASTP
9868399243561hypothetical proteinBLASTP
99389100015627hypothetical proteinBLASTP
100194100751558hypothetical proteinBLASTP
100880101068189hypothetical proteinBLASTP
101245101439195hypothetical proteinBLASTP
101504101749246hypothetical protein
101892102197306hypothetical protein
102269102427159hypothetical protein
102498102857360hypothetical proteinBLASTP
102972103247276hypothetical proteinBLASTP
103495103755261hypothetical protein
103926104279354hypothetical proteinBLASTP
104299104934636conserved phage proteinQuickGO ontologyBLASTP
1052671068171551hypothetical proteinBLASTP
1069071083191413HD domain proteinQuickGO ontologyBLASTP
108661109254594putative guanylate kinaseQuickGO ontologyBLASTP
109275109502228hypothetical proteinBLASTP
109727110482756hypothetical proteinBLASTP
110653110775123hypothetical protein
1109941120611068putative DNA modification methylaseQuickGO ontologyBLASTP
1121791136031425DNA primaseQuickGO ontologyBLASTP
113789114001213hypothetical proteinBLASTP
113970114107138hypothetical proteinBLASTP
114182114475294hypothetical protein
114573114863291hypothetical proteinBLASTP