Pre_GI: BLASTP Hits

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Query: NC_012654:92487:110994 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Start: 110994, End: 112061, Length: 1068

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010418:138325:1575091575091585761068Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completeDNA modification methylase0663
NC_010379:6880:241362413624906771Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequenceDNA modification methylase5e-143507
NC_017177:91993:105942105942106808867Clostridium difficile BI1, complete genomeputative DNA modification methylase2e-45183
NC_019897:3669888:367917136791713679782612Thermobacillus composti KWC4 chromosome, complete genomehypothetical protein3e-40166
NC_011295:1263500:127372212737221274705984Coprothermobacter proteolyticus DSM 5265, complete genomeputative DNA methylase3e-1686.7
NC_017095:1757935:176184517618451762681837Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeDNA methylase6e-1375.5
NC_013515:1125739:112713611271361127885750Streptobacillus moniliformis DSM 12112, complete genomeputative RNA methylase4e-1272.8
NC_013192:2381901:239588523958852396628744Leptotrichia buccalis DSM 1135, complete genomeputative RNA methylase3e-1066.6
NC_012778:1819559:183492418349241835472549Eubacterium eligens ATCC 27750, complete genomehypothetical protein3e-0756.6