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Query: NC_012654:92487:100194 Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequence

Start: 100194, End: 100751, Length: 558

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010379:6880:128201282013377558Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequencehypothetical protein3e-102370
NC_010418:138325:144656144656144877222Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completehypothetical protein1e-33142
NC_000964:2146000:219654021965402197055516Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein5e-27120
NC_014389:353000:356554356554357126573Butyrivibrio proteoclasticus B316 plasmid pCY360, completehypothetical protein1e-1582.8
NC_003228:2010643:206914720691472069764618Bacteroides fragilis NCTC 9343, complete genomehypothetical protein5e-1270.5
NC_016776:5174606:518175751817575182305549Bacteroides fragilis 638R, complete genomehypothetical protein3e-1064.7
NC_004663:2859158:286218628621862862758573Bacteroides thetaiotaomicron VPI-5482, complete genomehypothetical protein6e-0960.5
NC_006347:3285998:328720532872053287708504Bacteroides fragilis YCH46, complete genomehypothetical protein2e-0755.8