Pre_GI Gene

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Host: NC_007384 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007384:2933625 Shigella sonnei Ss046, complete genome

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. A leading cause of dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. This extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29331642933628465endopeptidase-like proteinQuickGO ontologyBLASTP
29336252934122498lysozyme-like proteinQuickGO ontologyBLASTP
29341222934337216lysis protein SQuickGO ontologyBLASTP
2935018293509275tRNA-GlyQuickGO ontology
2935096293517176tRNA-ThrQuickGO ontologyBLASTP
2935174293525077tRNA-ArgQuickGO ontologyBLASTP
2935252293532877tRNA-MetQuickGO ontology
29355182936279762putative bacteriophage proteinQuickGO ontologyBLASTP
29365622936948387antitermination protein Q-like proteinQuickGO ontologyBLASTP
29369382937309372putative endonucleaseQuickGO ontologyBLASTP
29373092937566258putative bacteriophage proteinQuickGO ontologyBLASTP
293756329390951533putative helicaseQuickGO ontologyBLASTP
29390702939909840IS2 ORF2QuickGO ontologyBLASTP
29399332940298366IS2 ORF1QuickGO ontologyBLASTP
29420922942235144hypothetical proteinBLASTP
294266429441421479hypothetical proteinBLASTP
29448452945348504IS1 ORFQuickGO ontologyBLASTP
2945408294548376tRNA-MetQuickGO ontologyBLASTP
29458092946312504IS1 ORFQuickGO ontologyBLASTP
294677229483251554putative enzymeQuickGO ontologyBLASTP
294855629496381083hypothetical proteinBLASTP
294959229509261335hypothetical proteinBLASTP
295094929523971449succinate-semialdehyde dehydrogenase NADP-dependent activityQuickGO ontologyBLASTP
2952411295369112814-aminobutyrate aminotransferase activityQuickGO ontologyBLASTP
295400229553181317transport permease protein of gamma-aminobutyrateQuickGO ontologyBLASTP
29553212956001681putative transcriptional regulatorQuickGO ontologyBLASTP
29560022956451450hypothetical proteinBLASTP
29565352956693159hypothetical proteinBLASTP
29568762957175300hypothetical proteinBLASTP
29571852957709525hypothetical proteinBLASTP