Pre_GI Gene

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Host: NC_005956 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005956:1521736 Bartonella henselae str. Houston-1, complete genome

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
152173615233701635Putative cell filamentation proteinQuickGO ontologyBLASTP
152353315254521920Conjugal transfer protein tragQuickGO ontologyBLASTP
152599415276221629hypothetical proteinBLASTP
152869215302901599Putative cell filamentation proteinQuickGO ontologyBLASTP
153076415323681605hypothetical proteinBLASTP
153269415340881395hypothetical proteinBLASTP
153442415369282505hypothetical proteinBLASTP
153711315402443132hypothetical proteinBLASTP