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Query: NC_005956:1521736 Bartonella henselae str. Houston-1, complete genome

Start: 1521736, End: 1540599, Length: 18864

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_005955:1259393*1259393127892419532Bartonella quintana str. Toulouse, complete genome01923BLASTN svgBLASTP svg
NC_020301:1449616*1449616147209922484Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genome01298BLASTN svgBLASTP svg
NC_012846:1679184*1679184170209922916Bartonella grahamii as4aup, complete genome01237BLASTN svgBLASTP svg
NC_010161:1811000*1811000183109920100Bartonella tribocorum CIP 105476, complete genome01150BLASTN svgBLASTP svg