Pre_GI: OUP Neighbours

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Query: NC_005956:1521736 Bartonella henselae str. Houston-1, complete genome

D: 24.4934

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.

Number of Neighbours: 4




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_005955:1259393*Bartonella quintana str. Toulouse, complete genome82.0588 %Subject ←→ Query23.094
NC_010161:1811000*Bartonella tribocorum CIP 105476, complete genome84.2739 %Subject ←→ Query27.9374
NC_012846:2004711*Bartonella grahamii as4aup, complete genome76.7402 %Subject ←→ Query27.95
NC_005956:1648000*Bartonella henselae str. Houston-1, complete genome76.152 %Subject ←→ Query31.2454