Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3992600 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39926003993034435hypothetical proteinBLASTP
39931563993563408hypothetical proteinBLASTP
39937223994147426mutTnudix family proteinQuickGO ontologyBLASTP
399431439954921179cell division protein FtsWRodASpoVE familyQuickGO ontologyBLASTP
399583439971531320dihydrolipoamide acetyltransferaseQuickGO ontologyBLASTP
399716939981529843-methyl-2-oxobutanoate dehydrogenase beta subunitQuickGO ontologyBLASTP
3998166399916710023-methyl-2-oxobutanoate dehydrogenase alpha subunitQuickGO ontologyBLASTP
399919540006161422dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
400062140017241104butyrate kinaseQuickGO ontologyBLASTP
400181240029121101leucine dehydrogenaseQuickGO ontologyBLASTP
40029474003846900phosphate acetyltransferaseQuickGO ontologyBLASTP
400404240061142073sensory box sigma-54 dependent DNA-binding response regulatorQuickGO ontologyBLASTP
40062514006484234hypothetical proteinBLASTP
40065334007261729glycerophosphoryl diester phosphodiesterase family proteinQuickGO ontologyBLASTP
400762640091521527hypothetical proteinBLASTP
40094504010280831stage 0 sporulation protein AQuickGO ontologyBLASTP
401053240118301299stage IV sporulation protein BQuickGO ontologyBLASTP