Pre_GI: BLASTP Hits

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Query: NC_005945:3992600:4007626 Bacillus anthracis str. Sterne, complete genome

Start: 4007626, End: 4009152, Length: 1527

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3992684:4007154400715440086801527Bacillus anthracis str. A0248, complete genomehypothetical protein0959
NC_003997:3993223:4007127400712740086531527Bacillus anthracis str. Ames, complete genomehypothetical protein0959
NC_007530:3992228:4007254400725440087801527Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein0959
NC_008600:3976045:3993526399352639950521527Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein0957
NC_016779:3913627:3928657392865739301831527Bacillus cereus F837/76 chromosome, complete genomeHemagglutinin, Hemagglutinin0957
NC_006274:4031246:4045370404537040468961527Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible hemagglutinin0957
NC_011773:3982008:3999477399947740010031527Bacillus cereus AH820 chromosome, complete genomehypothetical protein0957
NC_014335:3902155:3916649391664939181751527Bacillus cereus biovar anthracis str. CI chromosome, completehemagglutinin0957
NC_005957:3975192:3993730399373039952561527Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein0880
NC_020134:2067476:2067476206747620689391464Clostridium stercorarium subsp. stercorarium DSM 8532, completehypothetical protein1e-0758.5
NC_015067:2136048:2146908214690821484941587Bifidobacterium longum subsp. longum JCM 1217, complete genomehypothetical protein5e-0653.1
NC_014721:373607:3736073736073750431437Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehypothetical protein5e-0652.8
NC_015949:2101302:2123953212395321253891437Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomehypothetical protein5e-0652.8
NC_008526:1973500:1979045197904519806221578Lactobacillus casei ATCC 334, complete genomehypothetical protein6e-0652.8