Pre_GI: BLASTP Hits

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Query: NC_005945:3992600:3993156 Bacillus anthracis str. Sterne, complete genome

Start: 3993156, End: 3993563, Length: 408

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3992684:399268439926843993091408Bacillus anthracis str. A0248, complete genomehypothetical protein8e-66248
NC_007530:3992228:399278439927843993191408Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein8e-66248
NC_008600:3976045:397904139790413979487447Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein1e-63241
NC_016779:3913627:391418339141833914590408Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-63240
NC_011773:3982008:398500439850043985411408Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-63240
NC_005957:3975192:397925839792583979704447Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein6e-62235
NC_014171:4039120:403912040391204039527408Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-61233
NC_011772:4125996:412679541267954127202408Bacillus cereus G9842, complete genomehypothetical protein2e-60230
NC_010184:4021688:402397140239714024282312Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein1e-40164
NC_013406:3672857:368873236887323689148417Paenibacillus sp. Y412MC10 chromosome, complete genomeYjdF3e-1580.5
NC_014976:3469395:348847634884763488889414Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein1e-1478.2
NC_020244:1264500:127899812789981279411414Bacillus subtilis XF-1, complete genomehypothetical protein3e-1477
NC_007164:822000:831551831551832063513Corynebacterium jeikeium K411, complete genomehypothetical protein1e-0961.6