Pre_GI Gene

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Host: NC_012659 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012659:3992684 Bacillus anthracis str. A0248, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39926843993091408hypothetical proteinBLASTP
399384239950201179cell division protein FtsWRodASpoVE familyQuickGO ontologyBLASTP
399536239966811320branched-chain alpha-keto acid dehydrogenase subunit E2QuickGO ontologyBLASTP
399669739976809843-methyl-2-oxobutanoate dehydrogenase beta subunitQuickGO ontologyBLASTP
3997694399869510023-methyl-2-oxobutanoate dehydrogenase alpha subunitQuickGO ontologyBLASTP
399872340001441422dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
400014940012521104butyrate kinaseQuickGO ontologyBLASTP
400134040024401101leucine dehydrogenaseQuickGO ontologyBLASTP
40024754003374900phosphate butyryltransferaseQuickGO ontologyBLASTP
400357040056422073sensory box sigma-54 dependent DNA-binding response regulatorQuickGO ontologyBLASTP
40057794006012234hypothetical proteinBLASTP
40060614006789729glycerophosphoryl diester phosphodiesterase family proteinQuickGO ontologyBLASTP
40068404006986147hypothetical proteinBLASTP
400715440086801527hypothetical proteinBLASTP
40089784009808831stage 0 sporulation protein AQuickGO ontologyBLASTP
401006040113491290SpoIVB peptidaseQuickGO ontologyBLASTP