Pre_GI Gene

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Host: NC_007530 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007530:3992228 Bacillus anthracis str. 'Ames Ancestor', complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This is the type strain (0581, A2084, genotype 62, Group A3.b) for Bacillus anthracis and contains the two virulence plasmids, pOX1 and pOX2, that encode anthrax toxin and capsule, respectively, making this a virulent strain. This strain is considered the "gold standard" for B. anthracis. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39922283992662435hypothetical proteinBLASTP
39927843993191408hypothetical proteinBLASTP
39933503993775426muttnudix family proteinQuickGO ontologyBLASTP
399394239951201179cell division protein ftswrodaspove familyQuickGO ontologyBLASTP
399546239967811320dihydrolipoamide acetyltransferaseQuickGO ontologyBLASTP
399679739977809843-methyl-2-oxobutanoate dehydrogenase beta subunitQuickGO ontologyBLASTP
3997794399879510023-methyl-2-oxobutanoate dehydrogenase alpha subunitQuickGO ontologyBLASTP
399882340002441422dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
400024940013521104butyrate kinaseQuickGO ontologyBLASTP
400144040025401101leucine dehydrogenaseQuickGO ontologyBLASTP
40025754003474900phosphate acetyltransferaseQuickGO ontologyBLASTP
400367040057422073sensory box sigma-54 dependent dna-binding response regulatorQuickGO ontologyBLASTP
40058794006112234hypothetical proteinBLASTP
40061614006889729glycerophosphoryl diester phosphodiesterase family proteinQuickGO ontologyBLASTP
40069404007086147hypothetical proteinBLASTP
400725440087801527hypothetical proteinBLASTP
40090784009872795stage 0 sporulation protein aQuickGO ontologyBLASTP
401016040114581299stage iv sporulation protein bQuickGO ontologyBLASTP