Pre_GI: BLASTP Hits

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Query: NC_005945:3992600:4006251 Bacillus anthracis str. Sterne, complete genome

Start: 4006251, End: 4006484, Length: 234

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:3913627:392728239272823927515234Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-32137
NC_012659:3992684:400577940057794006012234Bacillus anthracis str. A0248, complete genomehypothetical protein2e-32137
NC_011969:3879412:389572638957263895959234Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-32137
NC_011773:3982008:399810239981023998335234Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-32137
NC_003997:3993223:400575240057524005985234Bacillus anthracis str. Ames, complete genomehypothetical protein2e-32137
NC_005957:3975192:399235639923563992589234Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-32137
NC_007530:3992228:400587940058794006112234Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-32137
NC_014335:3902155:391527439152743915507234Bacillus cereus biovar anthracis str. CI chromosome, completemetallo-beta-lactamase family protein2e-32137
NC_011725:4159000:417236741723674172600234Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-32136
NC_014171:4039120:405293540529354053168234Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-32136
NC_017208:4166008:417876041787604178993234Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-32136
NC_006274:4031246:404399540439954044228234Bacillus cereus E33L, complete genomehypothetical protein7e-32135
NC_011772:4125996:414060841406084140841234Bacillus cereus G9842, complete genomehypothetical protein7e-32135
NC_003909:3941282:395456539545653954798234Bacillus cereus ATCC 10987, complete genomehypothetical protein4e-31132
NC_004722:4117459:413021041302104130443234Bacillus cereus ATCC 14579, complete genomeIG hypothetical 173919e-31132
NC_010184:4021688:403778240377824038015234Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein4e-30129
NC_009674:2923707:293645929364592936692234Bacillus cytotoxicus NVH 391-98 chromosome, complete genomehypothetical protein1e-26118
NC_016593:2447938:245230924523092452557249Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completehypothetical protein3e-1580.5
NC_012793:2337776:235995023599502360198249Geobacillus sp. WCH70, complete genomehypothetical protein7e-1579.3