Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:3725397 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
372539737266981302cell division protein FtsAQuickGO ontologyBLASTP
37270713727868798cell division protein FtsQQuickGO ontologyBLASTP
37279673728872906UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
372893437300851152N-acetylglucosaminyl transferaseQuickGO ontologyBLASTP
373013437312251092stage V sporulation protein EQuickGO ontologyBLASTP
373131637326681353UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
37326693733643975phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
373366637351411476UDP-N-acetylmuramoylalanyl-D-glutamate--2 6-diaminopimelate ligaseQuickGO ontologyBLASTP
373535037372661917sporulation specific penicillin-binding proteinQuickGO ontologyBLASTP
373734837394982151penicillin-binding proteinQuickGO ontologyBLASTP
37395203739882363cell division protein FtsLQuickGO ontologyBLASTP
37398983740830933S-adenosyl-methyltransferase MraWQuickGO ontologyBLASTP
374120137428171617hypothetical proteinBLASTP
374289737437878912-dehydropantoate 2-reductaseQuickGO ontologyBLASTP
37441623744635474acetyltransferase GNAT familyQuickGO ontologyBLASTP
37446703745176507DNA-binding protein putativeQuickGO ontologyBLASTP
3745306374558427950S ribosomal protein L32QuickGO ontologyBLASTP
37455413746041501hypothetical proteinBLASTP
37464583747054597prophage LambdaBa02 lipoprotein putativeQuickGO ontologyBLASTP
37470873747710624hypothetical proteinBLASTP
374765237488331182prophage LambdaBa02 FtsKSpoIIIE family proteinQuickGO ontologyBLASTP