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Query: NC_005945:3725397:3727071 Bacillus anthracis str. Sterne, complete genome

Start: 3727071, End: 3727868, Length: 798

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3724729:372640337264033727200798Bacillus anthracis str. A0248, complete genomecell division protein FtsQ1e-129462
NC_003997:3724702:372637637263763727173798Bacillus anthracis str. Ames, complete genomecell division protein FtsQ1e-129462
NC_007530:3724829:372650337265033727300798Bacillus anthracis str. 'Ames Ancestor', complete genomecell division protein ftsq1e-129462
NC_014335:3675456:367716436771643677934771Bacillus cereus biovar anthracis str. CI chromosome, completecell division protein1e-123442
NC_016771:3665773:366748136674813668251771Bacillus cereus NC7401, complete genomecell division protein FtsQ1e-122438
NC_011772:3896635:389663538966353897405771Bacillus cereus G9842, complete genomecell division protein FtsQ3e-119427
NC_006274:3805134:380684238068423807612771Bacillus cereus E33L, complete genomecell division protein1e-118426
NC_005957:3746891:374859937485993749369771Bacillus thuringiensis serovar konkukian str. 97-27, completecell division protein1e-118426
NC_004722:3886800:388850738885073889277771Bacillus cereus ATCC 14579, complete genomeCell division protein ftsQ3e-118424
NC_011725:3928853:393056039305603931330771Bacillus cereus B4264 chromosome, complete genomecell division protein FtsQ8e-118423
NC_011969:3657360:365906836590683659838771Bacillus cereus Q1 chromosome, complete genomecell division protein2e-115415
NC_017208:3928161:392816139281613928736576Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecell division protein ftsQ6e-103373
NC_011999:813978:815323815323816213891Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein3e-1479