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Query: NC_005945:3725397:3747087 Bacillus anthracis str. Sterne, complete genome

Start: 3747087, End: 3747710, Length: 624

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003997:3724702:374658737465873747210624Bacillus anthracis str. Ames, complete genomehypothetical protein2e-110398
NC_007530:3724829:374671437467143747337624Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-110398
NC_005945:3747652:374708737470873747710624Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-110398
NC_012659:3724729:374661437466143747201588Bacillus anthracis str. A0248, complete genomehypothetical protein4e-103373
NC_017208:4887334:490878249087824909378597Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage protein2e-89328
NC_016771:3665773:368661436866143687246633Bacillus cereus NC7401, complete genomehypothetical protein3e-68258
NC_014915:2963500:296740029674002967996597Geobacillus sp. Y412MC52 chromosome, complete genomephage protein2e-1582.4
NC_013411:597235:635939635939636535597Geobacillus sp. Y412MC61, complete genomephage protein2e-1582.4