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Query: NC_005945:3725397 Bacillus anthracis str. Sterne, complete genome

Start: 3725397, End: 3748833, Length: 23437

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_007530:3724829*3724829374846023632Bacillus anthracis str. 'Ames Ancestor', complete genome031230BLASTN svgBLASTP svg
NC_003997:3724702*3724702376594941248Bacillus anthracis str. Ames, complete genome031230BLASTN svgBLASTP svg
NC_014335:3675456*3675456369934023885Bacillus cereus biovar anthracis str. CI chromosome, complete029780BLASTN svgBLASTP svg
NC_005957:3746891*3746891377074323853Bacillus thuringiensis serovar konkukian str. 97-27, complete029560BLASTN svgBLASTP svg
NC_006274:3805134*3805134382901423881Bacillus cereus E33L, complete genome029490BLASTN svgBLASTP svg
NC_004722:3886800*3886800391072823929Bacillus cereus ATCC 14579, complete genome018720BLASTN svgBLASTP svg
NC_011772:38966353896635391470718073Bacillus cereus G9842, complete genome018300BLASTN svgBLASTP svg
NC_005945:37476523747652376644918798Bacillus anthracis str. Sterne, complete genome02343BLASTN svgBLASTP svg