Pre_GI Gene

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Host: NC_004337 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004337:2478461 Shigella flexneri 2a str. 301, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24781782478480303IS911 ORF1QuickGO ontologyBLASTP
24784612479084624IS4 ORFQuickGO ontologyBLASTP
247938224808151434hypothetical proteinBLASTP
248082324818811059sucrose specific repressorQuickGO ontologyBLASTP
24820292482247219similar to high-affinity transport permease for gluconateQuickGO ontologyBLASTP
248226524835931329D-serine dehydrataseQuickGO ontologyBLASTP
248370124852391539multidrug resistance protein YQuickGO ontologyBLASTP
248523924864021164multidrug resistance protein KQuickGO ontologyBLASTP
24868182487432615putative positive transcription regulator sensor EvgSQuickGO ontologyBLASTP
248743724910303594putative sensor for regulator EvgAQuickGO ontologyBLASTP
249108624922311146putative enzymeQuickGO ontologyBLASTP
24923052493249945putative receptor proteinQuickGO ontologyBLASTP
249331924950131695hypothetical proteinBLASTP
249506724963171251formyl-coenzyme A transferaseQuickGO ontologyBLASTP
24968302497453624hypothetical proteinBLASTP
24981022498344243hypothetical proteinBLASTP
24986312499617987lipid A biosynthesis lauroyl acyltransferaseQuickGO ontologyBLASTP
250010825013461239hypothetical proteinBLASTP
25032242503958735putative 2-component transcriptional regulatorQuickGO ontologyBLASTP